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Cell Signaling Phospho-(Ser) Pkc Substrate Antibody
List Price
$430.00
Your Price
$430.00
Cell Signaling Phospho-(Ser) Pkc Substrate Antibody - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSSPQ-2261S
MFG.PART:
2261S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 200 µl |
| Reactivity | All |
| Sensitivity | Endogenous |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:25, Peptide ELISA (DELFIA): 1:500} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | Phospho-(Ser) PKC Substrate Antibody recognizes endogenous levels of many cellular proteins only when phosphorylated at serine residues surrounded by Arg or Lys at the -2 and +2 positions and a hydrophobic residue at the +1 position. The antibody does not cross-react with nonphosphorylated serine residues, with phospho-threonine in the same motif, or with phospho-serine in other motifs. |
| Species Reactivity | All Species Expected |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with synthetic phospho-PKC substrate peptides. Antibodies are purified by protein A and peptide affinity chromatography. |
| Background | Although protein kinase C (PKC) family members are involved in a number of signal transduction processes including secretion, gene expression, proliferation, and muscle contraction, many PKC substrates continue to be unidentified (1,2). Isozymes of PKC are subdivided into conventional PKCs (cPKC), novel PKCs (nPKC), and atypical PKCs (aPKC). PKCα, βI, βII, and γ isoforms belong to the cPKC group (1). When activated, cPKC isozymes phosphorylate substrates containing Ser or Thr, with Arg or Lys at the -3, -2, and +2 positions, and a hydrophobic amino acid at position +1 (1-3). |
| SKU | CSSPQ-2261S |
|---|---|
| Supplier Part Number | 2261S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |