Cell Signaling Ncbp1/Cbp80 (D7z2z) Rabbit mAb

Name: Cell Signaling Ncbp1/Cbp80 (D7z2z) Rabbit mAb
SKU: CSSPQ-24964S
Price: 351.00 USD

List Price $351.00 Your Price $351.00

Cell Signaling Ncbp1/Cbp80 (D7z2z) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-24964S

MFG.PART: 24964S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	80
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	NCBP1/CBP80 (D7Z2Z) Rabbit mAb recognizes endogenous levels of total NCBP1/CBP80 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro222 of human NCBP1/CBP80 protein.
Background	Nuclear cap-binding protein subunit 1 (NCBP1), also known as cap-binding protein 80 (CBP80), plays a role in nuclear pre-mRNA splicing (1,2). It has also been shown to function in the nonsense-mediated decay (NMD) of mRNAs where translation is prematurely terminated (3). NCBP1/CBP80 increases the efficiency of NMD by promoting the interaction of two active NMD components Upf1 and Upf2 (4).