Cell Signaling Mmp-7 (D4h5) Xp Rabbit mAb

Name: Cell Signaling Mmp-7 (D4h5) Xp Rabbit mAb
SKU: CSSPQ-3801T
Price: 159.00 USD

List Price $159.00 Your Price $159.00

Cell Signaling Mmp-7 (D4h5) Xp Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-3801T

MFG.PART: 3801T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	28, 20-22
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunohistochemistry (Paraffin): 1:100}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MMP-7 (D4H5) XP® Rabbit mAb detects endogenous levels of total MMP-7 protein.
Species Reactivity	Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile264 of mouse MMP-7 protein.
Background	The matrix metalloproteinases (MMPs) are a family of proteases that target many extracellular proteins including other proteases, growth factors, cell surface receptors, and adhesion molecules (1). Among the family members, MMP-2, MMP-3, MMP-7, and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis, and apoptosis (2-4). Research studies have shown that MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full-length protein (5).