Cell Signaling Mical1 (D8k7r) Rabbit mAb

Name: Cell Signaling Mical1 (D8k7r) Rabbit mAb
SKU: CSSPQ-41112S
Price: 351.00 USD

List Price $351.00 Your Price $351.00

Cell Signaling Mical1 (D8k7r) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-41112S

MFG.PART: 41112S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	130
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MICAL1 (D8K7R) Rabbit mAb recognizes endogenous levels of total MICAL1 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val1038 of human MICAL1 protein.
Background	Molecule interacting with CasL protein 1 (MICAL1) is a Protein-methionine sulfoxide oxidase. MICAL1 can bind directly to F-actin and oxidize specific methionine residues to promote actin filament disassembly (1-3). MICAL1 is an important component of semaphorin signaling cascades that has effects on cell movement, angiogenesis, immunology, diabetes, and cancer (2,4-6). MICAL1 binds to NDR1/2 and antagonizes MST1-induced NDR activation and apoptosis (7).