Cell Signaling Snap25 (A195) Antibody

Name: Cell Signaling Snap25 (A195) Antibody
SKU: CSSPQ-4117S
Price: 317.00 USD

List Price $317.00 Your Price $317.00

Cell Signaling Snap25 (A195) Antibody - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-4117S

MFG.PART: 4117S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	25
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	SNAP25 (A195) Antibody detects endogenous levels of total SNAP25 protein.
Species Reactivity	Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala195 of human SNAP25. Antibodies are purified by protein A and peptide affinity chromatography.
Background	The 25 kDa synaptosome-associated protein (SNAP25) is a target membrane soluble, N-ethylmaleimide-sensitive factor attachment protein receptor (t-SNARE) that is found on neuronal presynaptic membranes. SNAP25 forms a core complex with the SNARE proteins syntaxin and synaptobrevin to mediate synaptic vesicle fusion with the plasma membrane during Ca2+-dependent exocytosis (1). This complex is responsible for exocytosis of the neurotransmitter γ-aminobutyric acid (GABA). Neurotransmitter release is inhibited by proteolysis of SNAP25 by botulinum toxins A and E (2). SNAP25 plays a secondary role as a Q-SNARE involved in endosome fusion; the protein is associated with genetic susceptibility to attention-deficit hyperactivity disorder (ADHD) (3).