Cell Signaling Cd141/Thrombomodulin (E7y9p) Xp Rabbit mAb

Name: Cell Signaling Cd141/Thrombomodulin (E7y9p) Xp Rabbit mAb
SKU: CSSPQ-43514T
Price: 177.00 USD

List Price $177.00 Your Price $177.00

Cell Signaling Cd141/Thrombomodulin (E7y9p) Xp Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-43514T

MFG.PART: 43514T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	90
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:200, IHC Leica Bond: 1:100 - 1:400, Immunohistochemistry (Paraffin): 1:200 - 1:800}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #34149.
Specificity/Sensitivity	Thrombomodulin (E7Y9P) XP® Rabbit mAb recognizes endogenous levels of total CD141/Thrombomodulin protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with human CD141/Thrombomodulin recombinant protein.
Background	CD141/Thrombomodulin (TM, THBD, BDCA-3) is an integral membrane protein expressed on the surface of endothelial cells (1). Acting as a cofactor with Thrombin, CD141/Thrombomodulin activates and initiates the Protein C anticoagulant pathway (1-2). CD141/Thrombomodulin is expressed by a small subset of human CD11c+ myeloid dendritic cells (3-4). These CD141+XCR1+ dendritic cells cross-present antigens to naïve CD8+ T cells, priming them to become activated cytotoxic CD8+ T cells (3-5).