Cell Signaling Sdh5 (D1s8d) Rabbit mAb

Name: Cell Signaling Sdh5 (D1s8d) Rabbit mAb
SKU: CSSPQ-45849S
Price: 416.00 USD

List Price $416.00 Your Price $416.00

Cell Signaling Sdh5 (D1s8d) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-45849S

MFG.PART: 45849S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	15
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	SDH5 (D1S8D) Rabbit mAb recognizes endogenous levels of total SDH5 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala155 of human SDH5 protein.
Background	Succinate dehydrogenase subunit 5 (SDH5, SDHAF2) is a subunit of the succinate dehydrogenase (SDH) protein complex responsible for the oxidation of succinate during the citric acid cycle. Mitochondrial SDH5 associates with the catalytic subunit of succinate dehydrogenase and is required for adding FAD cofactor to the SDH catalytic subunit (1). Mutations in the corresponding SDHAF2 gene are associated with hereditary head and neck paragangliomas, an autosomal disorder characterized by the development of tumors with increased penetrance over time (1). Additional research studies show that SDH5 is involved in the regulation of lung cancer metastasis mediated by the glycogen synthase kinase 3β and β-catenin signaling pathways (2).

Specifications