Cell Signaling Stat2 Antibody (Mouse Specific)

Name: Cell Signaling Stat2 Antibody (Mouse Specific)
SKU: CSSPQ-4597S
Price: 317.00 USD

List Price $317.00 Your Price $317.00

Cell Signaling Stat2 Antibody (Mouse Specific) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-4597S

MFG.PART: 4597S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	130
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Stat2 Antibody detects endogenous levels of total mouse Stat2 protein.
Species Reactivity	Mouse
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse Stat2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Stat2 (113-kDa), originally purified from the nuclei of alpha-interferon-treated cells, is critical to the transcriptional responses induced by type I interferons, IFN-alpha/beta (1,2). Knockout mice with a targeted disruption of Stat2 have higher susceptibility to viral infection and altered responses to type I interferons (3). Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by IFN-alpha/beta via associations with receptor-bound Jak kinases (4). Unlike other Stat proteins, Stat2 does not form homodimers. Instead, activated Stat2 forms a heterodimer with Stat1 and translocates to the nucleus. There, it associates with the DNA-binding protein p48 and forms the transcriptional activator complex, interferon-stimulated gene factor 3 (ISGF3), promoting transcription from the ISRE (5).