Cell Signaling Tesk1 (D49d4) Rabbit mAb

Name: Cell Signaling Tesk1 (D49d4) Rabbit mAb
SKU: CSSPQ-4655T
Price: 152.00 USD

List Price $152.00 Your Price $152.00

Cell Signaling Tesk1 (D49d4) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-4655T

MFG.PART: 4655T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	68
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	TESK1 (D49D4) Rabbit mAb detects endogenous levels of total TESK1 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to carboxy terminal residues of human TESK1 protein.
Background	Testis-specific kinase 1 (TESK1) is a LIMK-related protein kinase originally identified to be expressed highly in testes and subsequently shown to be expressed in a wide variety of tissues and cell types (1-4). TESK1 phosphorylates the actin severing protein cofilin at Ser3, inactivating cofilin and thus regulating the organization of the actin cytoskeleton (2). Integrin signaling activates TESK1 activity and leads to stress fiber formation and cell spreading (2,5,6). TESK1 is involved in regulation of ERK signaling through its interaction with Spry2 (7) and regulation of cell spreading through its interaction with the focal adhesion protein actopaxin/α-parvin (5).