Cell Signaling Wrn (8h3) Mouse mAb

Name: Cell Signaling Wrn (8h3) Mouse mAb
SKU: CSSPQ-4666T
Price: 169.00 USD

List Price $169.00 Your Price $169.00

Cell Signaling Wrn (8h3) Mouse mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-4666T

MFG.PART: 4666T

UNSPSC: 41116111

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	200
Source/Isotype	Mouse IgG1
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	WRN (8H3) Mouse mAb detects endogenous levels of total WRN protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with full length human recombinant WRN protein.
Background	The RecQ family of DNA and RNA helicases is a family of enzymes that has been shown to be important to genome integrity (1). Members of this family function in several DNA repair processes including double strand break repair, homologous recombination, and re-initiation of DNA replication at stalled replication forks (2,3). Mutations in RecQ helicase family members results in syndromes that display varying types of chromosomal abnormalities and overall genomic instability (1). WRN is a member of the RecQ family that has been identified as the gene underlying Werner’s syndrome; an autosomal recessive disorder characterized by premature aging and predisposition to cancer (4). Cells from Werner’s Syndrome patients exhibit genomic instability that is associated with deficient DNA repair activity (5).