Cell Signaling Chronophin/Pdxp (C85e3) Rabbit mAb

Name: Cell Signaling Chronophin/Pdxp (C85e3) Rabbit mAb
SKU: CSSPQ-4686T
Price: 148.00 USD

List Price $148.00 Your Price $148.00

Cell Signaling Chronophin/Pdxp (C85e3) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-4686T

MFG.PART: 4686T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H M R Hm Mk B
Sensitivity	Endogenous
Molecular Weight (kDa)	31
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Chronophin/PDXP (C85E3) Rabbit mAb detects endogenous levels of total chronophin/PDXP protein.
Species Reactivity	Human, Mouse, Rat, Hamster, Monkey, Bovine
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant mouse MBP-chronophin.
Background	Cofilin is a conserved actin-severing protein required for processes that rely on actin dynamics, including cytokinesis and cell motility (reviewed in 1). Regulation of actin dynamics requires the controlled cycling between the phosphorylated and unphosphorylated forms of cofilin (2). The severing activity of cofilin is inhibited by LIMK or TESK phosphorylation at the conserved amino-terminal Ser3 of cofilin (3,4). Slingshot (SSH) phosphatase, for which there have been three mammalian isoforms identified, dephosphorylates cofilin in vivo (5). Chronophin (CIN, PDXP) is a haloacid dehalogenase phosphatase that also dephosphorylates cofilin. Alteration of CIN activity through overexpression of either the wildtype or phosphatase-inactive mutant CIN interferes with actin dynamics, cell morphology and cytokinesis (6).