Cell Signaling Caspase-8 Antibody (Mouse Specific)

Name: Cell Signaling Caspase-8 Antibody (Mouse Specific)
SKU: CSSPQ-4927T
Price: 135.00 USD

List Price $135.00 Your Price $135.00

Cell Signaling Caspase-8 Antibody (Mouse Specific) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-4927T

MFG.PART: 4927T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	45, 57
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Caspase-8 Antibody detects endogenous levels of mouse caspase-8 protein.
Species Reactivity	Mouse
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a region within the large 18 kDa subunit of mouse caspase-8. Antibodies were purified by protein A and peptide affinity chromatography.
Background	Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage.