Cell Signaling Androgen Receptor (D6f11) Xp Rabbit mAb

Name: Cell Signaling Androgen Receptor (D6f11) Xp Rabbit mAb
SKU: CSSPQ-5153T
Price: 182.00 USD

List Price $182.00 Your Price $182.00

Cell Signaling Androgen Receptor (D6f11) Xp Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-5153T

MFG.PART: 5153T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	110
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:2000, Simple Western™: 1:50 - 1:250, Immunoprecipitation: 1:50, Immunohistochemistry (Paraffin): 1:200 - 1:800, Immunofluorescence (Immunocytochemistry): 1:600 - 1:1200, Flow Cytometry (Fixed/Permeabilized): 1:400 - 1:800, Chromatin IP: 1:100, Chromatin IP-seq: 1:100, CUT&RUN: 1:100}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #23791.
Specificity/Sensitivity	Androgen Receptor (D6F11) XP® Rabbit mAb detects endogenous levels of total androgen receptor protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein corresponding to residues near the amino terminal region of human androgen receptor protein.
Background	Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. Research studies have shown that AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3).

Specifications