Cell Signaling Phospho-Thr-Pro-Pro Motif (D61c3) Rabbit mAb

Name: Cell Signaling Phospho-Thr-Pro-Pro Motif Ptpp (D61c3) Rabbit mAb
SKU: CSSPQ-5757S
Price: 415.00 USD

List Price $415.00 Your Price $415.00

Cell Signaling Phospho-Thr-Pro-Pro Motif [Ptpp] (D61c3) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-5757S

MFG.PART: 5757S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	All
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Phospho-Thr-Pro-Pro Motif [pTPP] (D61C3) Rabbit mAb recognizes endogenous levels of proteins only when phosphorylated within the TPP motif. It does not cross react with phospho-serine or phospho-threonine in other contexts.
Species Reactivity	All Species Expected
Source/Purification	Monoclonal antibody is produced by immunizing animals with synthetic peptide library containing the phospho-Thr-Pro-Pro motif.
Background	The phospho-Thr-Pro-Pro motif is a subgroup of the phospho-Thr-Pro motif that is phosphorylated by proline-directed protein kinases, including MAP kinases and cyclin dependent kinases (CDKs). Proline-directed phosphorylation is one of the major regulatory phosphorylation events in cell proliferation, cell differentiation, and a number of other essential cellular processes (1-6). This motif was identified in both phospho-proteomic and motif X analyses as a significant phospho-thr motif (7,8).