Cell Signaling Arg3.1 (D6h9n) Rabbit mAb

Name: Cell Signaling Arg3.1 (D6h9n) Rabbit mAb
SKU: CSSPQ-65650S
Price: 351.00 USD

List Price $351.00 Your Price $351.00

Cell Signaling Arg3.1 (D6h9n) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-65650S

MFG.PART: 65650S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	51
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Arg3.1 (D6H9N) Rabbit mAb recognizes endogenous levels of total Arg3.1 protein. A band of unknown origin is detected ~40kDa in some rodent samples.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val209 of human Arg3.1 protein.
Background	Arg3.1, also known as Arc for activity-regulated cytoskeleton-associated protein, is an immediate early gene whose expression is necessary for synaptic plasticity (1). Arg3.1 expression is induced by many experimental stimuli such as LTP (2), LTD (3), and learning. Arg3.1 is also involved in the regulation of synaptic strength and homeostatic scaling by promoting AMPA receptors endocytosis (5,6). Arg3.1 dysregulation has been proposed to participate in cognitive decline during aging (7).