Cell Signaling Atf-6 (D4z8v) Rabbit mAb

Name: Cell Signaling Atf-6 (D4z8v) Rabbit mAb
SKU: CSSPQ-65880T
Price: 152.00 USD

List Price $152.00 Your Price $152.00

Cell Signaling Atf-6 (D4z8v) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-65880T

MFG.PART: 65880T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	90-100
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ATF-6 (D4Z8V) Rabbit mAb recognizes endogenous levels of total ATF-6 alpha protein. The antibody does not detect ATF-6 beta protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ATF-6 alpha protein.
Background	Activating Transcription Factor-6 (ATF-6) is a transmembrane glycoprotein of the endoplasmic reticulum (ER). Upon accumulation of improperly folded proteins in the ER, ATF-6 is cleaved liberating a 50 kDa amino-terminal fragment that translocates to the nucleus (1, 2). There, ATF-6 activates transcription of ER chaperones and components of ER-associated degradation such as GRP78, XBP-1, and CHOP (3-5).