Cell Signaling Androgen Receptor (D6f11) Xp Rabbit mAb (Alexa Fluor 488 Conjugate)

Name: Cell Signaling Androgen Receptor (D6f11) Xp Rabbit mAb (Alexa Fluor 488 Conjugate)
SKU: CSSPQ-7395S
Price: 465.00 USD

List Price $465.00 Your Price $465.00

Cell Signaling Androgen Receptor (D6f11) Xp Rabbit mAb (Alexa Fluor 488 Conjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-7395S

MFG.PART: 7395S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunofluorescence (Immunocytochemistry): 1:400, Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	Androgen Receptor (D6F11) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate) detects endogenous levels of total androgen receptor protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a recombinant protein corresponding to residues near the amino terminal region of human androgen receptor protein.
Background	Androgen receptor (AR), a zinc finger transcription factor belonging to the nuclear receptor superfamily, is activated by phosphorylation and dimerization upon ligand binding (1). This promotes nuclear localization and binding of AR to androgen response elements in androgen target genes. Research studies have shown that AR plays a crucial role in several stages of male development and the progression of prostate cancer (2,3).