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Cell Signaling Phospho-Cxcr4 (Ser324/Ser325) Antibody
List Price $362.00 Your Price $362.00
Cell Signaling Phospho-Cxcr4 (Ser324/Ser325) Antibody - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSSPQ-85578S
MFG.PART: 85578S
UNSPSC: 12352203
Manufacturer: Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 45-60 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | Phospho-CXCR4 (Ser324/Ser325) Antibody recognizes endogenous levels of CXCR4 protein only when phosphorylated at Ser324 and Ser325. This antibody does not cross-react with CXCR4 protein when phosphorylated at Ser339. |
| Species Reactivity | Human |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser324/Ser325 of human CXCR4 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Background | CXCR4 is a chemokine receptor that belongs to the g protein-coupled receptor family. It is activated by a small cytokine, CXCL12, also known as stromal cell derived factor 1 (SDF1) (1). The main function of CXCR4 is the mediation of the homing of progenitor cells in the bone marrow and their recruitment to sites of injury (2). More recently, CXCR4 has been studied, as a potential therapeutic target, in the context of autoimmune diseases (3) as well as cancer, as the receptor is involved in the regulation of migration, proliferation, and survival of cancer cells (4).CXCR4 is rapidly phosphorylated at Ser324 and Ser325 by protein kinase C and g protein-coupled receptor kinase 6 upon treatment of cells with CXCL12 (2). Phosphorylation of CXCR4 at Ser324/Ser325 is critical to the ubiquitination and degradation of CXCR4 (6,7). |
| SKU | CSSPQ-85578S |
|---|---|
| Supplier Part Number | 85578S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |