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Cell Signaling Ikappabalpha (L35a5) Mouse mAb (Amino-Terminal Antigen) (Alexa Fluor 647 Conjugate)
List Price $465.00 Your Price $465.00
Cell Signaling Ikappabalpha (L35a5) Mouse mAb (Amino-Terminal Antigen) (Alexa Fluor 647 Conjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSSPQ-8993S
MFG.PART: 8993S
UNSPSC: 12352203
Manufacturer: Cell Signaling
| Size | 100 µl (50 tests) |
| Reactivity | H M R Mk B Pg |
| Sensitivity | Endogenous |
| Source/Isotype | Mouse IgG1 |
| Application/Dilution | {Flow Cytometry (Fixed/Permeabilized): 1:50} |
| Storage | Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. |
| Specificity/Sensitivity | IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total IκBα protein. |
| Species Reactivity | Human, Mouse, Rat, Monkey, Bovine, Pig |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a GST-IκBα fusion protein corresponding the amino terminus of human IκBα protein. |
| Background | The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB (3-7). IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified (8). |
| SKU | CSSPQ-8993S |
|---|---|
| Supplier Part Number | 8993S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | +4C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |