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Cell Signaling Sdf1/Cxcl12 (D8g6h) Rabbit mAb (Ihc-Specific)
List Price $351.00 Your Price $351.00
Cell Signaling Sdf1/Cxcl12 (D8g6h) Rabbit mAb (Ihc-Specific) - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSSPQ-97958S
MFG.PART: 97958S
UNSPSC: 41116124
Manufacturer: Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 10 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Immunohistochemistry (Paraffin): 1:200} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #89194. |
| Specificity/Sensitivity | SDF1/CXCL12 (D8G6H) Rabbit mAb recognizes endogenous levels of total SDF1/CXCL12 protein by immunohistochemistry on paraffin-embedded tissue sections. This antibody recognizes both SDF1/CXCL12α and SDF1/CXCL12β. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein specific to human SDF1/CXCL12 protein. |
| Background | The stromal cell derived factor 1 (SDF1/CXCL12) is a small, pro-inflammatory chemoattractant cytokine that regulates leukocyte trafficking through interactions with its cognate 7-transmembrane g protein-coupled receptors (1). The SDF1/CXCL12 receptor, CXCR4, also serves as a coreceptor for the entry of human immunodeficiency virus into target cells (2). SDF1/CXCL12 may regulate homing and maintenance of CXCR4-expressing stem or progenitor cells, including embryonic and many somatic stem cells (3,4). Many cancer cells express CXCR4, suggesting that SDF1/CXCL12 plays a role in cancer metastasis (5,6). Alternative splicing and differential processing during maturation produce a pair of SDF1/CXCL12 isoforms (SDF1/CXCL12α and SDF1/CXCL12β) that have different properties and biological activities (7). Additional isoforms of SDF1/CXCL12 have been reported (8,9). |
| SKU | CSSPQ-97958S |
|---|---|
| Supplier Part Number | 97958S |
| UM | EA |
| UNSPSC | 41116124 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |