Cell Signaling 4-1bbl/Cd137l/Tnfsf9 (E8w3p) Rabbit mAb

Name: Cell Signaling 4-1bbl/Cd137l/Tnfsf9 (E8w3p) Rabbit mAb
SKU: CSSPQ-90204S
Price: 369.00 USD

List Price $369.00 Your Price $369.00

Cell Signaling 4-1bbl/Cd137l/Tnfsf9 (E8w3p) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-90204S

MFG.PART: 90204S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	28
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunoprecipitation: 1:100, IHC Leica Bond: 1:300 - 1:1200, Immunohistochemistry (Paraffin): 1:50 - 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #26596.
Specificity/Sensitivity	4-1BBL/CD137L/TNFSF9 (E8W3P) Rabbit mAb recognizes endogenous levels of total 4-1BBL/CD137L/TNFSF9 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human 4-1BBL/CD137L/TNFSF9 protein.
Background	TNFRSF9 is a member of the tumor necrosis factor receptor superfamily (1,2). It is also called 4-1BB or CD137 (1, 2). 4-1BB/CD137/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5). The ligand 4-1BBL/CD137L/TNFSF9 on antigen presenting cells binds to 4-1BB/CD137/TNFRSF9 and costimulates the activation of T cells (5). The binding of agonistic antibodies to 4-1BB/CD137/TNFRSF9 also leads to costimulation for T cell activation (5). Studies have shown the effectiveness of targeting 4-1BB/CD137/TNFRSF9 by its agonistic antibodies in cancer immunotherapy (6).