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Cell Signaling Flash/Casp8ap2 (D3t8q) Rabbit mAb
List Price
$351.00
Your Price
$351.00
Cell Signaling Flash/Casp8ap2 (D3t8q) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSSPQ-43339S
MFG.PART:
43339S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 223 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | FLASH/CASP8AP2 (D3T8Q) Rabbit mAb recognizes endogenous levels of total FLASH/CASP8AP2 protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein specific to residues near the amino terminus of human FLASH/CASP8AP2 protein. |
| Background | FLICE associated huge protein (FLASH), also termed Caspase 8 associated protein 2 (CASP8AP2), is a large multifunctional protein that has been shown to be involved in multiple processes, including apoptosis, cell cycle progression, and transcriptional regulation (1-3). It was originally identified as a component of the FAS-FADD-Caspase 8 complex with a role in the activation of caspase-8 during Fas-mediated apoptosis (1). However, studies suggest additional functions for FLASH/CASP8AP2 in the nucleus within Cajal and PML bodies (3-5). One of the functions identified was its ability to regulate histone gene processing and S-phase progression (3,6). FLASH/CASP8AP2 has also been found to regulate the activity of transcription factors, including the glucocorticoid receptor and c-Myb (2,7). Furthermore, FLASH/CASP8AP2 was found to stabilize the expression of ZEB1, a transcriptional repressor of genes associated with epithelial-to-mesenchymal transition (EMT), a process associated with cancer metastasis (8). Aberrant expression as well as genetic mutations in the FLASH/CASP8AP2 gene have been described in several cancers and it has been suggested to be a prognostic indicator in acute lymphoblastic leukemia (9-14). |
| SKU | CSSPQ-43339S |
|---|---|
| Supplier Part Number | 43339S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |