Cell Signaling Cav2.3/Cacna1e Antibody

Name: Cell Signaling Cav2.3/Cacna1e Antibody
SKU: CSSPQ-42437S
Price: 317.00 USD

List Price $317.00 Your Price $317.00

Cell Signaling Cav2.3/Cacna1e Antibody - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-42437S

MFG.PART: 42437S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	257
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Cav2.3/CACNA1E Antibody recognizes endogenous levels of total Cav2.3 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1039 of mouse Cav2.3 protein. Antibodies are purified by peptide affinity chromatography.
Background	Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells. VSCCs are involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. Calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 is encoded by the CACNA1E gene (1,2). In the brain, Cav2.3 has been implicated in synaptic plasticity (3,4). Interestingly, Cav2.3 may contribute to some neurodegenerative diseases like Parkinson’s disease (5).