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Cell Signaling Ncr1/Nkp46 (E2k4n) Rabbit mAb
List Price $351.00 Your Price $351.00
Cell Signaling Ncr1/Nkp46 (E2k4n) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSSPQ-23732S
MFG.PART: 23732S
UNSPSC: 12352203
Manufacturer: Cell Signaling
| Size | 100 µl |
| Reactivity | M |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 50-60 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:100} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | NCR1/NKp46 (E2K4N) Rabbit mAb recognizes endogenous levels of total NCR1/NKp46 protein. |
| Species Reactivity | Mouse |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of mouse NCR1/NKp46 protein. |
| Background | The family of natural cytotoxicity receptors (NCRs) contains NCR1 (NKp46/CD335), NCR2 (NKp44/CD336), and NCR3 (NKp30/CD337). They are single-pass type I transmembrane proteins belonging to the immunoglobin (Ig) superfamily. Various pathogen-derived as well as host-encoded molecules have been identified as ligands for the NCRs. They were originally identified by their ability to evoke the cytotoxicity of natural killer (NK) cells towards tumor cells in vitro and animal models have demonstrated that NCRs play a role in vivo in tumor surveillance, viral infection, and pregnancy (1-5).NCR1/NKp46 is considered a universal marker for NK cells, and recent studies found that it is also expressed by other cells, such as group 1 innate lymphoid cells (ILC1), a subset of group 3 ILCs (NCR+ ILC3), and γδ T cells (2-4). NCR1/NKp46 is also expressed on and considered as a diagnostic marker and therapeutic target for some malignant NK, NKT, and T cell lymphomas (6,7). Cross-linking NCR1/NKp46 with antibodies can activate NK cells and this has been pursued as a promising therapeutic avenue (8). |
| SKU | CSSPQ-23732S |
|---|---|
| Supplier Part Number | 23732S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |