Cell Signaling Mthfd2 (E7a4l) Xp Rabbit mAb (Alexa Fluor 488 Conjugate)

Name: Cell Signaling Mthfd2 (E7a4l) Xp Rabbit mAb (Alexa Fluor 488 Conjugate)
SKU: CSSPQ-86804S
Price: 465.00 USD

List Price $465.00 Your Price $465.00

Cell Signaling Mthfd2 (E7a4l) Xp Rabbit mAb (Alexa Fluor 488 Conjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-86804S

MFG.PART: 86804S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunofluorescence (Immunocytochemistry): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	MTHFD2 (E7A4L) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate) recognizes endogenous levels of total MTHFD2 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu340 of human MTHFD2 protein.
Background	MTHFD2 is a bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase involved in mitochondrial folate metabolism (1). MTHFD2 expression is developmentally regulated, as it is expressed in embryos but not in most adult tissues. Recent research studies have shown that MTHFD2 is consistently overexpressed in many cancer types and correlated with poor survival in breast cancer (2-5). Overexpression of MTHFD2 promotes cell proliferation while its depletion induces cell death in human cancer cells (6).