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Cell Signaling Lrba Antibody
List Price
$317.00
Your Price
$317.00
Cell Signaling Lrba Antibody - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSSPQ-86622S
MFG.PART:
86622S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 320 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | LRBA Antibody recognizes endogenous levels of total LRBA protein. This antibody detects a 130 kDa band of unknown origin in some cell lines. |
| Species Reactivity | Human |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human LRBA protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Background | LRBA (lipopolysaccharide responsive beige-like anchor protein) is a 300 kDa intracellular protein that is a member of the pH-BEACH-WD40 protein family (1-3). Its BEACH domain contains an A-kinase anchoring protein (AKAP) motif, known to have an affinity for signaling enzymes (1,3). LRBA has been found to be overexpressed in several different cancers, such as renal, pancreas, colorectal, and lung (2). LRBA deficiency, caused by various mutations, can cause common variable immune deficiency (CVID) as well as other immune dysregulations (3,5). LRBA plays an immunoregulatory role to CTLA-4, protecting it from being degraded within lysosomes (4,6). In LRBA deficiency, CTLA-4 is synthesized normally, but is not delivered to Rab GTPase recycling compartments, instead resulting in enhanced lysosome degradation (4,6,7). |
| SKU | CSSPQ-86622S |
|---|---|
| Supplier Part Number | 86622S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |