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Cell Signaling Cox2/Mt-Co2 (E6u9k) Rabbit mAb
List Price
$351.00
Your Price
$351.00
Cell Signaling Cox2/Mt-Co2 (E6u9k) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSSPQ-50003S
MFG.PART:
50003S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 19 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | COX2/MT-CO2 (E6U9K) Rabbit mAb recognizes endogenous levels of total COX2/MT-CO2 protein. |
| Species Reactivity | Human, Monkey |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly222 of human COX2/MT-CO2 protein. |
| Background | The electron transport chain (or respiratory chain) is a series of mitochondrial protein complexes (Complexes I-IV) that utilize coupled reduction-oxidation (redox) reactions to transfer electrons from donor molecules to acceptors. By coupling this electron transport with active proton pumping across the inner mitochondrial membrane, an electrochemical gradient is generated that is used to drive ATP synthesis (1). Complex IV (cytochrome c oxidase) is the terminal complex of the respiratory chain, responsible for transporting electrons from cytochrome c to molecular oxygen. COX2 (cytochrome c oxidase subunit 2), also known as MT-CO2, is one of 14 subunits of cytochrome c oxidase, and one of three subunits (COX1/MT-CO1, COX2/MT-CO2, and COX3/MT-CO3) encoded by the mitochondrial genome (2). These three mitochondrial-encoded subunits form the functional core of cytochrome c oxidase. Research studies have shown that disruptions to COX2/MT-CO2 function can have deleterious health effects. For example, a novel point mutation in the COX2/MT-CO2 gene was identified as a risk factor for cardiovascular disease (3), whereas a separate point mutation was causally linked to adult onset cerebellar ataxia (4). |
| SKU | CSSPQ-50003S |
|---|---|
| Supplier Part Number | 50003S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |