Cell Signaling Lyve-1 (E3l3v) Rabbit mAbjugate)

Name: Cell Signaling Lyve-1 (E3l3v) Rabbit mAbjugate)
SKU: CSSPQ-69240S
Price: 465.00 USD

List Price $465.00 Your Price $465.00

Cell Signaling Lyve-1 (E3l3v) Rabbit mAbjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-69240S

MFG.PART: 69240S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	M R
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunofluorescence (Frozen): 1:50 - 1:100}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	LYVE-1 (E3L3V) Rabbit mAb (Alexa Fluor® 488 Conjugate) recognizes endogenous levels of total LYVE-1 protein.
Species Reactivity	Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of mouse LYVE-1 protein.
Background	Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1), also known as extracellular link domain-containing protein 1 (XLKD1), is a type I integral membrane glycoprotein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells, but has also been described on hepatic blood sinusoidal endothelia, embryonic blood vessels, Kupffer cells, the islets of Langerhans, cortical neurons, and renal epithelium (1-3). LYVE-1 acts as a receptor for hyaluronan, and plays a role in hyaluronan transport and turnover (4-7). LYVE-1 also mediates the docking and entry of dendritic cells to lymphatic vessels through selective adhesion to hyaluronan in the leukocyte surface glycocalyx (8). Several studies have demonstrated the utility of LYVE-1 as a marker for lymphoid tissues and lymphangiogenesis (9,10).