Cell Signaling Serpinb9 (E9j8j) Xp ® Rabbit mAb

Name: Cell Signaling Serpinb9 (E9j8j) Xp ® Rabbit mAb
SKU: CSSPQ-37908T
Price: 180.00 USD

List Price $180.00 Your Price $180.00

Cell Signaling Serpinb9 (E9j8j) Xp ® Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-37908T

MFG.PART: 37908T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	42
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunohistochemistry (Paraffin): 1:200 - 1:800}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	SERPINB9 (E9J8J) XP® Rabbit mAb recognizes endogenous levels of total SERPINB9 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with human SERPINB9 recombinant protein and reacts with an epitope surrounding Phe70.
Background	SERPINB9 (Sb9, PI-9) is a member of the serpin superfamily of proteins which bind to and inactivate serine proteinases (1,2). SERPINB9 is present in human CD4+ T cells, CD8+ T cells, NK cells, B cells, and myeloid cells, and is a physiological inhibitor of Granzyme B (GrB) (1,3,4). Granzyme B triggers apoptosis when released by cytotoxic T lymphocytes (1-4). SERPINB9 may function to protect effector and bystander cells from Granzyme B during an immune response (4). In mice, SPI6 is thought to be the functional homolog of SERPINB9 due to its inhibition of murine Granzyme B (2,5). SERPINB9 was recently identified as a potential immunotherapy target, due to its role in tumor cell survival through evasion of apoptosis (6).