Cell Signaling Cd7 (E4g1q) Xp ® Rabbit mAb

Name: Cell Signaling Cd7 (E4g1q) Xp ® Rabbit mAb
SKU: CSSPQ-32814T
Price: 178.00 USD

List Price $178.00 Your Price $178.00

Cell Signaling Cd7 (E4g1q) Xp ® Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-32814T

MFG.PART: 32814T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	38-40
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, IHC Leica Bond: 1:200 - 1:800, Immunohistochemistry (Paraffin): 1:50 - 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #19673.
Specificity/Sensitivity	CD7 (E4G1Q) XP® Rabbit mAb recognizes endogenous levels of total CD7 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu59 of human CD7 protein.
Background	CD7 is a type-I transmembrane glycoprotein belonging to the immunoglobulin superfamily. CD7 is one of the earliest surface markers to be expressed on the surface of developing T cells and its expression is maintained throughout maturation of multiple T cell subsets and NK cells (1-3). Engagement of CD7 through binding its ligand, SECTM1, has been shown to promote tyrosine phosphorylation of its cytoplasmic domain, recruitment of PI3K, and delivery of costimulatory signals for T cell activation (4-6). While CD7 is expressed on normal T cells, it is also highly expressed in a variety of T cell malignancies, which has poised it as a potential target of immunotherapy (7-9).