Cell Signaling Ccl5/Rantes (E9s2k) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Ccl5/Rantes (E9s2k) Rabbit mAb (BSA And Azide Free)
SKU: CSSPQ-57219SF
Price: 865.00 USD

List Price $865.00 Your Price $865.00

Cell Signaling Ccl5/Rantes (E9s2k) Rabbit mAb (BSA And Azide Free) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-57219SF

MFG.PART: 57219SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	10
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #36467.
Specificity/Sensitivity	CCL5/RANTES (E9S2K) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CCL5/RANTES protein. This antibody recognizes human CCL5/RANTES protein and is also reactive with mouse CCL5/RANTES; however, this antibody is not suggested for immunohistochemical analysis of mouse tissues. Non-specific staining was observed in human pancreatic islets by immunohistochemistry.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with human CCL5/RANTES recombinant protein.
Background	RANTES/CCL5 (regulated upon activation, T cell expressed and secreted) is a member of the "C-C" or β family of chemokines that induce inflammation and are associated with a number of inflammatory disorders (1,2). RANTES is produced and secreted mainly by CD8+ T cells, macrophages, and platelets, as well as epithelial cells, fibroblasts, and some solid tumors (2-7). RANTES acts as a chemoattractant and has other regulatory functions on a number of cell types, including monocytes, memory T cells, NK cells, eosinophils, basophils, dendritic cells, and mast cells (3, 7-9). Signaling by RANTES is mediated by several g protein-coupled receptors (GPCRs), including CCR1, CCR3, CCR4, and CCR5.