We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cell Signaling Ut-B/Slc14a1 (E3s8j) Rabbit mAb
List Price
$351.00
Your Price
$351.00
Cell Signaling Ut-B/Slc14a1 (E3s8j) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSSPQ-44897S
MFG.PART:
44897S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 28-65 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | UT-B/SLC14A1 (E3S8J) Rabbit mAb recognizes endogenous levels of total UT-B/SLC14A1 protein. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala380 of human UT-B/SLC14A1 protein. |
| Background | Urea transporter B (UT-B, also known as UT1) is encoded by the SLC14A1 gene (1). Urea transporters (UTs) are multipass membrane proteins that transport urea down a concentration gradient. Urea is an organic compound composed of two amino groups and a linked carbamoyl group. Urea is a metabolic waste product of the liver and is excreted via the kidney. UT-B/SLC14A1 was first cloned from human erythrocytes (2). UT-B is not only expressed in endothelial cells of the renal medulla but is also expressed in other organs, including the brain, heart, and pancreas, suggesting broad physiological functions. In the brain, UT-B may be expressed in astrocytes to maintain urea concentrations in the central nervous system. Animals lacking UT-B exhibit depression-like behaviors, suggesting that regulation of urea levels in the brain may be important for proper neuronal function (3). |
| SKU | CSSPQ-44897S |
|---|---|
| Supplier Part Number | 44897S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |