Cell Signaling Cxcr5 (D6l3c) Rabbit mAb (Ihc Specific) (BSA And Azide Free)

Name: Cell Signaling Cxcr5 (D6l3c) Rabbit mAb (Ihc Specific) (BSA And Azide Free)
SKU: CSSPQ-99825SF
Price: 865.00 USD

List Price $865.00 Your Price $865.00

Cell Signaling Cxcr5 (D6l3c) Rabbit mAb (Ihc Specific) (BSA And Azide Free) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-99825SF

MFG.PART: 99825SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #72172.
Specificity/Sensitivity	CXCR5 (D6L3C) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total CXCR5 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domains of human CXCR5 protein.
Background	CXCR5 is a g protein-coupled receptor belonging to the chemokine receptor subfamily (1). Upon binding of its ligand, the chemokine CXCL13, CXCR5 initiates multiple intracellular signaling pathways that regulate cell proliferation, survival, and migration (2). CXCR5 is expressed in both mature B cells and follicular helper T cells, and responds to CXCL13 gradient to control lymphocyte migration towards secondary lymphoid tissues (3). CXCR5 has also been shown to be highly expressed in primary breast tumors, in correlation with their propensity to grow and metastasize (4).