Cell Signaling B7-H6 (E9q7l) Rabbit mAb

Name: Cell Signaling B7-H6 (E9q7l) Rabbit mAb
SKU: CSSPQ-20617S
Price: 351.00 USD

List Price $351.00 Your Price $351.00

Cell Signaling B7-H6 (E9q7l) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-20617S

MFG.PART: 20617S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunoprecipitation: 1:200, Flow Cytometry (Fixed/Permeabilized): 1:400 - 1:1600, Flow Cytometry (Live): 1:50 - 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	B7-H6 (E9Q7L) Rabbit mAb recognizes endogenous levels of total B7-H6 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro185 of human B7-H6 protein.
Background	B7-H6 (NCR3LG1) is a member of the B7 family of proteins which provide costimulatory signals for regulating T cell responses (1-3). B7-H6 is a ligand for the NK-cell–activating receptor NKp30, which triggers anti-tumor natural killer (NK) cell cytotoxicity and cytokine secretion (1). Both forms of B7-H6, cell surface B7-H6 and soluble B7-H6 (sB7-H6), are detected in primary tumors and the tumor microenvironment, but rarely in normal tissues (1-5). Cell surface B7-H6 associates with cell damage, and triggers innate immunity when it binds to NKp30 on NK cells (3,5). Soluble B7-H6 can decrease NKp30 expression on NK cells and induce NK cell dysfunction (4,5).