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Cell Signaling Beta2a-Tubulin Antibody
List Price
$317.00
Your Price
$317.00
Cell Signaling Beta2a-Tubulin Antibody - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSSPQ-51658S
MFG.PART:
51658S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 55 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | β2A-Tubulin Antibody recognizes endogenous levels of total β2A-tubulin protein. This antibody does not cross-react with β2B-tubulin protein. |
| Species Reactivity | Human, Mouse, Rat |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser201 of human β2A-tubulin protein. Antibodies are purified by peptide affinity chromatography. |
| Background | The cytoskeleton consists of three types of cytosolic fibers: microtubules, microfilaments (actin filaments), and intermediate filaments. Globular tubulin subunits comprise the microtubule building block, with α/β-tubulin heterodimers forming the tubulin subunit common to all eukaryotic cells. γ-tubulin is required to nucleate polymerization of tubulin subunits to form microtubule polymers. Many cell movements are mediated by microtubule action, including the beating of cilia and flagella, cytoplasmic transport of membrane vesicles, chromosome alignment during meiosis/mitosis, and nerve-cell axon migration. These movements result from competitive microtubule polymerization and depolymerization or through the actions of microtubule motor proteins (1).Tubulinopathies cover a spectrum of disorders affecting neuronal development. Mutations in β-tubulin genes, including the β2A-tubulin gene TUBB2A, are associated with cortical and extracortical malformations, leading to cognitive deficits and epilepsy (2). β2A-tubulin has also been associated with the formation of tau inclusions, and is a suggested biomarker for breast cancer metastasis (3,4). |
| SKU | CSSPQ-51658S |
|---|---|
| Supplier Part Number | 51658S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |