Cell Signaling Zap-70 (D1c10e) Xp Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Zap-70 (D1c10e) Xp Rabbit mAb (BSA And Azide Free)
SKU: CSSPQ-69022SF
Price: 865.00 USD

List Price $865.00 Your Price $865.00

Cell Signaling Zap-70 (D1c10e) Xp Rabbit mAb (BSA And Azide Free) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-69022SF

MFG.PART: 69022SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	70
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #3165
Specificity/Sensitivity	Zap-70 (D1C10E) XP® Rabbit mAb (BSA and Azide Free) detects endogenous levels of total Zap-70. This antibody does not cross-react with other related proteins.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the amino terminus of human Zap-70.
Background	The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement (1). Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck (2-6). Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia (7,8).