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Cell Signaling Cps1/Hep Par-1 (Och1e5) Mouse mAb (Clone Previously Known As Hepatocyte Specific Antigen)
List Price
$354.00
Your Price
$354.00
Cell Signaling Cps1/Hep Par-1 (Och1e5) Mouse mAb (Clone Previously Known As Hepatocyte Specific Antigen) - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSSPQ-96422S
MFG.PART:
96422S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Source/Isotype | Mouse IgG1 |
| Application/Dilution | {Immunohistochemistry (Paraffin): 1:100 - 1:400} |
| Storage | Supplied in a PBS-based buffer containing sodium azide as a preservative. Stable for 12 months when stored at 4°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | CPS1/Hep Par-1 (OCH1E5) Mouse mAb (Clone previously known as Hepatocyte Specific Antigen) recognizes endogenous levels of total CPS1/Hep Par-1 protein, which is present in the liver and small intestine. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with human liver fixed in formalin. |
| Background | Carbamoyl phosphate synthetase 1 (CPS1), a rate-limiting enzyme in the urea cycle, catalyzes the conversion of ammonia and bicarbonate to carbamoyl phosphate in mitochondria. Non-small cell lung carcinoma (NSCLC) cells with oncogenic KRAS and loss of the tumor suppressor LKB1 express CPS1 and depend on this enzyme for growth. CPS1 maintains pyrimidine/purine balance in these cancer cells. Silencing CPS1 reduces the pyrimidine to purine ratio and stalls DNA synthesis, leading to DNA damage and cancer cell death (1). In addition, the tumor suppressor p53 represses the expression of urea cycle enzymes CPS1, OTC, and ARG1 and, therefore, causes the accumulation of ammonia, suppressing cancer growth (2). Furthermore, research studies suggest that hypermethylation-mediated downregulation of CPS1 expression may contribute to the progression of normal hepatocytes to hepatocellular carcinoma (HCC) (3). CPS1 was identified to be the antigen detected by Hep Par-1 antibody (4). |
| SKU | CSSPQ-96422S |
|---|---|
| Supplier Part Number | 96422S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | +4C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |