Cell Signaling Acbp/Dbi (E4v8v) Xp ® Rabbit mAb

Name: Cell Signaling Acbp/Dbi (E4v8v) Xp ® Rabbit mAb
SKU: CSSPQ-40487T
Price: 178.00 USD

List Price $178.00 Your Price $178.00

Cell Signaling Acbp/Dbi (E4v8v) Xp ® Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-40487T

MFG.PART: 40487T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	10
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunohistochemistry (Paraffin): 1:500 - 1:2000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ACBP/DBI (E4V8V) XP® Rabbit mAb recognizes endogenous levels of total ACBP/DBI protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a recombinant human ACBP/DBI protein.
Background	Acyl-CoA-binding protein (ACBP) binds to long-chain acyl-CoA molecules and regulates lipid metabolism. This protein is also known as diazepam-binding inhibitor (DBI) and binds to the benzodiazepine-binding site of the γ-aminobutyric acid (GABA) type A receptor (GABAAR), regulating its activity (1). ACBP/DBI is highly expressed in glioblastoma and promotes glioblastoma growth by providing long-chain acyl-CoA molecules to mitochondria for fatty acid oxidation. Reduced ACBP/DBI expression leads to slower proliferation of glioblastoma (2,3). In addition, ACBP/DBI is a regulator of neural progenitor and stem cell proliferation in adult mouse neurogenic niches (4,5). Studies show that ACBP/DBI modulates embryonic neurogenesis of excitatory and inhibitory neurons through GABA signaling (6).