Cell Signaling 4e-Bp1 (53h11) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling 4e-Bp1 (53h11) Rabbit mAb (BSA And Azide Free)
SKU: CSSPQ-42235SF
Price: 865.00 USD

List Price $865.00 Your Price $865.00

Cell Signaling 4e-Bp1 (53h11) Rabbit mAb (BSA And Azide Free) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-42235SF

MFG.PART: 42235SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	15-20
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #9644
Specificity/Sensitivity	4E-BP1 (53H11) Rabbit mAb (BSA and Azide Free) detects endogenous levels of total 4E-BP1 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	4E-BP1 (53H11) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to residues surrounding Ser112 of human 4E-BP1.
Background	Translation repressor protein 4E-BP1 (also known as PHAS-1) inhibits cap-dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E-BP1 disrupts this interaction and results in activation of cap-dependent translation (1). Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E-BP1 activity (2,3). Multiple 4E-BP1 residues are phosphorylated in vivo (4). While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E-BP1 to eIF4E, it is thought to prime 4E-BP1 for subsequent phosphorylation at Ser65 and Thr70 (5).

Specifications