Cell Signaling Eea1 (C45b10) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Eea1 (C45b10) Rabbit mAb (BSA And Azide Free)
SKU: CSSPQ-65014SF
Price: 865.00 USD

List Price $865.00 Your Price $865.00

Cell Signaling Eea1 (C45b10) Rabbit mAb (BSA And Azide Free) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-65014SF

MFG.PART: 65014SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	170
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #3288
Specificity/Sensitivity	EEA1 (C45B10) Rabbit mAb (BSA and Azide Free) detects endogenous levels of total EEA1 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser70 of human EEA1 protein.
Background	EEA1 is an early endosomal marker and a Rab5 effector protein essential for early endosomal membrane fusion and trafficking (1-2). The carboxy terminus of EEA1 contains a FYVE domain which binds to phosphatidylinositol-3-phosphate (PtdIns(3)P), targeting EEA1 to early endosomes (3). The stable association of EEA1 with the endosomal membrane is regulated by PI3 kinase, Rab5 and calcium/calmodulin (4-6). Once on the membrane, EEA1 interacts with Rab5, NSF and syntaxin 13 to promote early endosomal membrane docking and fusion (7).

Specifications