Cell Signaling Phospho-Gsk-3beta (Ser9) (D85e12) Xp ® Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Phospho-Gsk-3beta (Ser9) (D85e12) Xp ® Rabbit mAb (BSA And Azide Free)
SKU: CSSPQ-79774SF
Price: 898.00 USD

List Price $898.00 Your Price $898.00

Cell Signaling Phospho-Gsk-3beta (Ser9) (D85e12) Xp ® Rabbit mAb (BSA And Azide Free) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-79774SF

MFG.PART: 79774SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H M R Hm
Sensitivity	Endogenous
Molecular Weight (kDa)	46
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #5558
Specificity/Sensitivity	Phospho-GSK-3β (Ser9) (D85E12) XP® Rabbit mAb (BSA and Azide Free) detects endogenous levels of GSK-3β only when phosphorylated at Ser9. This antibody reacts with denatured components of bovine serum, including BSA.
Species Reactivity	Human, Mouse, Rat, Hamster
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser9 of human GSK-3β.
Background	Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5).