Cell Signaling Rbm4 (E1y2g) Rabbit mAb

Name: Cell Signaling Rbm4 (E1y2g) Rabbit mAb
SKU: CSSPQ-61689S
Price: 376.00 USD

List Price $376.00 Your Price $376.00

Cell Signaling Rbm4 (E1y2g) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-61689S

MFG.PART: 61689S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	41
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunofluorescence (Immunocytochemistry): 1:50 - 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	RBM4 recognizes endogenous levels of total RBM4 protein. This antibody does not cross-react with RBM4B protein.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro317 of human RBM4 protein.
Background	RBM4 functions as an RNA-binding protein and precursor mRNA splicing factor that antagonizes activity of PTBP1-mediated splicing (1-4). Upon phosphorylation at Ser309, RBM4 accumulates in stress granules and suppresses cap-dependent translation through eIF4A (3). Exon skipping of MEF2C by RBM4 has been shown to play a key role in the differentiation of brown adipocytes (5). The splicing activities of RBM4 seem to suppress tumorigenesis in the context of multiple cancer types (5-8).