Cell Signaling Msh2 (D24b5) Xp ® Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Msh2 (D24b5) Xp ® Rabbit mAb (BSA And Azide Free)
SKU: CSSPQ-37698SF
Price: 865.00 USD

List Price $865.00 Your Price $865.00

Cell Signaling Msh2 (D24b5) Xp ® Rabbit mAb (BSA And Azide Free) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-37698SF

MFG.PART: 37698SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	100
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #2017
Specificity/Sensitivity	MSH2 (D24B5) XP® Rabbit mAb (BSA and Azide Free) detects endogenous levels of total MSH2 protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues at the amino terminus of human MSH2.
Background	The DNA mismatch repair system (MMR) repairs post-replication DNA, inhibits recombination between non-identical DNA sequences and induces both checkpoint and apoptotic responses following certain types of DNA damage (1). MSH2 (MutS homologue 2) forms the hMutS-α dimer with MSH6 and is an essential component of the mismatch repair process. hMutS-α is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins and the Rad50-Mre11-NBS1 complex (2).Mutations in MSH2 have been found in a large proportion of hereditary non-polyposis colorectal cancer (Lynch Syndrome), the most common form of inherited colorectal cancer in the Western world (3). Mutations have also been associated with other sporadic tumors.