Cell Signaling Il-6ralpha/Cd126 (E5b3p) Rabbit mAb (Alexa Fluor ® 647 Conjugate)

Name: Cell Signaling Il-6ralpha/Cd126 (E5b3p) Rabbit mAb (Alexa Fluor ® 647 Conjugate)
SKU: CSSPQ-98797S
Price: 465.00 USD

List Price $465.00 Your Price $465.00

Cell Signaling Il-6ralpha/Cd126 (E5b3p) Rabbit mAb (Alexa Fluor ® 647 Conjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-98797S

MFG.PART: 98797S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Live): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	IL-6Rα/CD126 (E5B3P) Rabbit mAb (Alexa Fluor® 647 Conjugate) recognizes endogenous levels of total IL-6Rα/CD126 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human IL-6Rα/CD126 protein.
Background	The IL-6 receptor is a heterodimeric complex that consists of a ligand-binding IL-6 receptor α (IL-6Rα) subunit and a signaling component, gp130 (1). Binding of IL-6 to IL-6Rα results in receptor dimerization with gp130 and subsequent STAT3 activation (1). IL-6Rα is cleaved from the cell surface by ADAM17 (1,2). In humans, soluble IL-6Rα is also generated via alternatively spliced mRNA (1,3). Soluble IL-6Rα binds to IL-6 and can stimulate signaling via membrane bound gp130 in a process known as “trans-signaling” (1). It is through trans-signaling that IL-6 stimulates cells that do not express membrane bound IL-6Rα (1).

Specifications