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Cell Signaling Rbm9 (E7w6u) Rabbit mAb
List Price $376.00 Your Price $376.00
Cell Signaling Rbm9 (E7w6u) Rabbit mAb - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSSPQ-37315S
MFG.PART: 37315S
UNSPSC: 12352203
Manufacturer: Cell Signaling
| Size | 100 µl |
| Reactivity | H Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 50, 60 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:100} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | RBM9 (E7W6U) Rabbit mAb recognizes endogenous levels of total RBM9 protein. This antibody detects multiple isoforms of RBM9. |
| Species Reactivity | Human, Monkey |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala77 of human RBM9 protein. |
| Background | RBM9, also known as RBFOX2, is an RNA-binding protein involved in the regulation of tissue specific alternative splicing (1). RBM9 is widely expressed in many tissues throughout various developmental stages. Several isoforms of this protein are generated by variable use of multiple alternatively spliced internal exons and alternative splice sites (2-4). RBM9 is predominantly localized in the nucleus, where it regulates alternative pre-mRNA splicing. This factor was also identified to be a novel constituent of cytoplasmic stress granules (SGs), and its RNA binding activity is necessary for its localization into SGs (5). Notably, RBM9 dissociation from SGs suppresses cancer progression (6). The splicing-regulatory role of RBM9 has also been implicated as a tumor suppressor in pancreatic ductal adenocarcinoma (PDA) and could serve as a therapeutic approach for metastatic PDA (7). |
| SKU | CSSPQ-37315S |
|---|---|
| Supplier Part Number | 37315S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |