Cell Signaling Gstp1 (3f2) Mouse mAb (BSA And Azide Free)

Name: Cell Signaling Gstp1 (3f2) Mouse mAb (BSA And Azide Free)
SKU: CSSPQ-10130SF
Price: 865.00 USD

List Price $865.00 Your Price $865.00

Cell Signaling Gstp1 (3f2) Mouse mAb (BSA And Azide Free) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-10130SF

MFG.PART: 10130SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	23
Source/Isotype	Mouse IgG1
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #3369
Specificity/Sensitivity	GSTP1 (3F2) Mouse mAb (BSA and Azide Free) detects endogenous levels of total GSTP1 protein. The antibody does not cross react with GST-tagged proteins.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant GSTP1 protein.
Background	Glutathione S-transferases (GSTs) are a family of isoenzymes that detoxify electrophiles through conjugation to thiol-reduced glutathione (GSH). Thus, they are critical in protecting cells from toxins (drugs, pesticides, carcinogens) and oxidative stress (1). Eight isoforms of cytosolic-soluble GSTs (α, κ, μ, π, σ, θ, ζ, and ω) are identified, while only GST-α, -μ, and -π are described in the central nervous system (2). GSTP1 (GSTπ) is overexpressed in early stages of carcinogenesis and can be used as a neoplastic marker in tumor tissues (3). GSTP1 directly inhibits TRAF2 and JNK but not NF-κB (4,5). Corresponding GSTP1 gene polymorphisms affect substrate selectivity and stability, and the oxidative milieu in dopaminergic neurons, which increases the susceptibility to Parkinson’s disease (6).

Specifications