Cell Signaling Timp1 (D10e6) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Timp1 (D10e6) Rabbit mAb (BSA And Azide Free)
SKU: CSSPQ-76074SF
Price: 865.00 USD

List Price $865.00 Your Price $865.00

Cell Signaling Timp1 (D10e6) Rabbit mAb (BSA And Azide Free) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-76074SF

MFG.PART: 76074SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	26
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #8946
Specificity/Sensitivity	TIMP1 (D10E6) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total TIMP1 protein.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala134 of human TIMP1 protein.
Background	TIMPs are members of the family of tissue inhibitor of matrix metalloproteinases (MMPs) that includes TIMP1, TIMP2, TIMP3, and TIMP4. The main function of TIMPs is their inhibitory effect on MMPs. TIMPs irreversibly inactivate MMPs by direct binding to their catalytic zinc cofactor and resultant inhibition of proteinase function (1,2). In addition to MMP inhibition, TIMPs have also been shown to interact with various membrane receptors on the cell surface. Some of these interactions include: TIMP1 with CD63, TIMP2 with α3β1 integrin, and TIMP3 with VEGFR2, all of which result in distinct cellular effects (3). TIMPs are involved in a wide variety of biological functions, such as tumor angiogenesis and progression (4,5), wound healing, and vascular remodeling (6,7). Mutations in TIMP3 are associated with Sorsbys fundus dystrophy (8,9).