Cell Signaling Cleaved Parp (Asp214) (D6x6x) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Cleaved Parp (Asp214) (D6x6x) Rabbit mAb (BSA And Azide Free)
SKU: CSSPQ-96256SF
Price: 898.00 USD

List Price $898.00 Your Price $898.00

Cell Signaling Cleaved Parp (Asp214) (D6x6x) Rabbit mAb (BSA And Azide Free) - CSSPQ (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSSPQ-96256SF

MFG.PART: 96256SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	89
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #94885
Specificity/Sensitivity	Cleaved PARP (Asp214) (D6X6X) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of the large fragment (89 kDa) of PARP protein only when cleaved at Asp214.
Species Reactivity	Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp214 of rodent PARP1 protein.
Background	PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress (1). This protein can be cleaved by many ICE-like caspases in vitro (2,3) and is one of the main cleavage targets of caspase-3 in vivo (4,5). In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA-binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa) (2,4). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis (6).

Specifications