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Cell Signaling Anti-Biotin (D5a7) Rabbit mAb (PE Conjugate)
List Price $280.00 Your Price $280.00
Cell Signaling Anti-Biotin (D5a7) Rabbit mAb (PE Conjugate) - CSSPQ (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSSPQ-39681S
MFG.PART: 39681S
UNSPSC: 12352203
Manufacturer: Cell Signaling
| Size | 250 µl |
| Reactivity | Rab |
| Sensitivity | Endogenous |
| Source/Isotype | Rabbit |
| Application/Dilution | {} |
| Storage | Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze. |
| Specificity/Sensitivity | Anti-biotin (D5A7) Rabbit mAb (PE Conjugate) recognizes biotin attached to proteins, peptides, oligonucleotides, and solid matrices. |
| Species Reactivity | Rabbit |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with biotinylated KLH. |
| Background | Biotin is a water-soluble B complex vitamin (vitamin H or B7) that serves as a coenzyme in various metabolic functions. It transfers carbon dioxide for five carboxylase enzymes and is involved in the TCA cycle and gluconeogenesis. In addition, all cells require biotin for cell proliferation, production of fatty acids, and metabolism of fats and amino acids (1). Biotin recycling and attachment to histone proteins is catalyzed by an enzyme named biotinidase. Histone biotinylation is involved in regulating telomere attrition and cellular senescence. Biotinidase deficiency is a rare genetic disorder that can cause neurological and cutaneous symptoms if left untreated (2). Biotin has a high affinity for its natural ligand, avidin. The complex and irregular structure of the biotin-binding site makes it highly optimized for biotin binding and confers great specificity to the avidin-biotin complexes (3). This remarkable affinity has been exploited for numerous immunoassays, including ELISA, Flow Cytometry, Immunofluorescence, In Situ Hybridization, Affinity Chromatography, and Immunohistochemistry. Anti-biotin (D5A7) Rabbit mAb #5597 can be used as an alternative to avidins in order to minimize background and maximize signal intensity. |
| SKU | CSSPQ-39681S |
|---|---|
| Supplier Part Number | 39681S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | +4C |
| CountryOfOrigin | United States |
| ProductLine | CSSPQ |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |