Sigma-Aldrich Quictpd# Negative Control Set

N-Methylated Pomalidomide is a ligand used as a negative control for pomalidomide in the recuitment of Cereblon (CRBN) protein, whereas (S,S,S) AHPC-hydrochloride is a ligand used as negative control for (S,R,S)-AHPC in the recruitment of von-Hippel Lindau (VHL) protein. N-methylation of pomalidomide or the inversion of stereochemistry to yield of (S,S,S) AHPC prevents binding to CRBN and VHL proteins. These are provided at 10mg each.

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Useful for construction of small molecules structurally similar to PROTACs of interest but with no inherent degradation action in themselves serving as negative control.

Structural similarity to active CRBN/VHL ligands is optimal for construction of negative controls. The amino terminus in each can be used for attaching bifunctional linkers with reactions such as peptide coupling.

Negative Control Set part of QuicTPD^™ kit

QuicTPD is a trademark of Merck KGaA, Darmstadt, Germany